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NICOTINE EP
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CAS NO.
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56-11-5
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Formula
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Description
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Colorless to Brownish viscous Liquid
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Identification:
(a) IR Spectrum
(b) UV Spectrum
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The IR Spectrum of the test sample should match with the IR spectrum of Ph.
Eur.
Should comply with the test of specific optical rotation.
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Appearance of Solution
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The solution is clear and not more intensely coloured than reference solution
Y5,BY5 or R5
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Specific Optical Rotation
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Between -140º and -152º Celsius
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Water Content
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0.5% max
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Related substances by HPLC
Specified impurities
Anatabine
ß- Nicotryine
Cotinine
Myosmine
Nicotine N’oxide
Nomicotine
Anatabine
Any Unspecified Impurity (single greatest)
Sum of impurities (Identified and Unidentified)
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Not more than 0.3%
Not more than 0.3%
Not more than 0.3%
Not more than 0.3%
Not more than 0.3%
Not more than 0.3%
Not more than 0.3%
Not more than 0.1%
Not more than 0.8%
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Assay
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99-101%
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Packing
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5/10/20/50Kg Drum with Nitrogen.
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APPLICATION
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Used Active Pharmaceutical Intermediate to Manufacture other salts of Nicotine.
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